CTRL-SHIFT-DEL. Job done, you cunning swine. Take the afternoon off!
Right-clicking in the Developer Tools Network tab gives an option to clear the cache. Like this:
Kill it. Kill it with fire
Alternatively, just disable the damned thing altogether. This is available via the often-overlooked Settings for Chrome’s Developer Tools. To access these, click the little cog at the bottom right of Developer Tools, as circled below:
Then, on the General tab, there’s an option to disable the cache:
Check that, and you’re golden. Take the rest of the week off. Hell, quit your job! It can’t possibly get better than this.
Here’s a skateboarding duck: